Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

NJ Hannan; S Beard; NK Binder; K Onda; TJ Kaitu'u-Lino; Q Chen; L Tuohey; M De Silva; S Tong

Journal article

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

NJ Hannan, S Beard, NK Binder, K Onda, TJ Kaitu'u-Lino, Q Chen, L Tuohey, M De Silva, S Tong

Placenta | W B SAUNDERS CO LTD | Published : 2017

DOI: 10.1016/j.placenta.2017.01.002

Abstract

Introduction Preeclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of perinatal morbidity and mortality. Placental insufficiency is central to these conditions. The mechanisms underlying placental insufficiency are poorly understood. Apoptosis has long been considered the only form of regulated cell death, recent research has identified an alternate process of programmed cell death known as necroptosis [1]. Necroptosis is distinct from apoptosis, relying on the deacetylase sirtuin-2 [2], receptor interacting kinases RIPK1 and 3, and the pseudokinase MLKL [3]. We aimed to determine whether these key necroptosis effector molecules were present in human placenta and ..

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University of Melbourne Researchers

Natalie Hannan Author

Natalie Binder Author

Tu'uhevaha Kaitu'u-Lino Author

Stephen Tong Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

National Health and Medical Research Council (NHMRC) of Australia grant (#1061977, #1048707) and salary support from the NHMRC (#1050765, #1062418, #628927) and a University of Melbourne C R Roper Research Fellowship.